test prop

When applied topically penetrates the focus of inflammation through test prop the skin, absorption of ketoprofen from the inflammatory focus is extremely slow (gel bioavailability – about 5%). After application of a dose of 50-150 mg of ketoprofen concentration in plasma after 5-8 hours of 0.08-0.15 g / ml. Virtually accumulates in the body.

Indications

  • muscle pain (myositis, myalgia);
  • muscle and bone and joint pain rheumatic origin (eg, osteoarthritis);
  • the pain of traumatic origin (bruises, sprains and muscle sprains);
  • strength and stiffness of the neck muscles;
  • lumbago.

Contraindications

  • individual hypersensitivity to ketoprofen or other components of the drug, acetylsalicylic acid or other NSAIDs (indicate a history of bronchospasm, urticaria or rhinitis caused by the intake of acetylsalicylic acid) and fenofibrate;
  • moist dermatitis, eczema, infected abrasions, wounds;
  • Children up to age 12 years;
  • pregnancy and lactation.

Carefully

  • severe renal insufficiency.

Dosage and administration:
For external use only.
When using the tube to squeeze out a small amount of gel (3-5 cm) and apply a thin layer 1-2 times a day on the injured area, or skin inflammation on the hearth and gently rub.
If you use a container with a dispenser ( dispenser) to put pressure on the dome of the dispenser (Figure 1) or on the base of the dispenser (fig. 2) until the gel. It is recommended to keep the container with pump in a horizontal position. Apply about 3-5 cm gel 1 to 2 times a day on the injured area, or skin over the fire of inflammation and lightly rub.

The amount of gel can vary on the size of the treated area.
Can be used in conjunction with physical test prop therapy (phonophoresis and iontophoresis).

Side effects are
very rare – allergic reactions, photosensitivity, contact dermatitis, erythema, rash, itching, dermatitis bulezny. In case of any side effects you must stop using the product and seek medical advice.
In very rare cases (less than 0.01%) may be violations of the gastrointestinal tract haemorrhage, diarrhea, peptic ulcer.

Overdose
is extremely low systemic absorption of the active components of the preparation for external application makes it virtually impossible overdose.

Interaction with other drugs
When applied topically in the form of ketoprofen gel may increase the effect of drugs that cause photosensitivity. Other interactions have not been established. However, you should consult a physician before using the gel, if you are using coumarin anticoagulants.

Cautions
Do not apply to damaged and inflamed skin!
Avoid contact with eyes (risk of irritation of the conjunctiva).
Do not apply in the form of occlusive dressings. Do not use in conjunction with a sealed (airtight) clothing.
Prolonged use of topical agents can lead to increased sensitivity or local irritation. In order to avoid any hypersensitivity manifestations or photosensitivity, avoid exposure to direct sunlight .
Patients with severe renal insufficiency Caution should be exercised when using test prop .

Effect on ability to drive vehicles and management mechanisms
The  does not affect the ability to drive vehicles and work requiring high concentration.

testosterone propionate cycle

Inhibitors of microsomal oxidation testosterone propionate cycle reduce the risk of hepatotoxicity. Long-term sharing of paracetamol and others. Nonsteroidal anti-inflammatory drugs increase the risk of “analgesic” nephropathy and renal papillary necrosis, onset of end-stage renal failure.

Simultaneous administration of paracetamol in prolonged high doses of salicylates and increases the risk of kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% – the risk of hepatotoxicity.

Myelotoxicity drugs increase the expression gematotoksichnosti drug.

Conditional pheniramine:
Antidepressants, antipsychotics and antiparkinsonian (phenothiazines) drugs increase the risk of side effects pheniramine (urinary retention, dry mouth, constipation), glkzhokortikosteroidy  increase the risk of developing glaucoma.

Conditional ascorbic acid:
Increases blood concentration of penicillin and tetracyclines; at a dose of 1 g / day of ethinyl estradiol increases the bioavailability (including a member of the oral contraceptives).

Improves the intestinal absorption of iron (ferric iron translates into divalent.

Reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid , oral contraceptives, fresh juices and alkaline water reduces the absorption and assimilation.

In an application with increased urinary excretion of ascorbic acid and reduced excretion testosterone propionate cycle.

It increases the risk of crystalluria in the treatment of salicylates and sulfonamides short-acting, slow excretion by the kidneys of acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), lowers blood levels of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.

PM quinoline series, calcium chloride, salicylates, corticosteroids prolonged use deplete ascorbic acid.

With prolonged use or application in high doses may interfere with the interaction of disulfiram and ethanol.

In high doses, increases excretion of mexiletine kidneys.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

It reduces the therapeutic effect of anti-psychotic drugs (neuroleptics) – phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Special instructions:
The drug should not be taken simultaneously with other testosterone propionate cycle medications containing acetaminophen and ascorbic acid.

High doses of ascorbic acid enhance the excretion of oxalate, contributing to the formation of kidney stones.

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones necessary to monitor the function – of the adrenal glands and blood pressure.

Ascorbic acid as a reducing agent can distort the results of the various laboratory tests (blood and urine glucose content in the blood plasma – bilirubin, activity of “liver” transaminases and lactate dehydrogenase, uric acid).

During the period of treatment should refrain from testosterone propionate cycle the use of ethanol (development of hepatotoxicity), motor vehicles and other driving activities potentially hazardous activities that require high concentration and psychomotor speed reactions.

testosterone propionate

Paracetamol has analyeziruyuschim and antipyretic action. Pheniramine – blocker of testosterone propionatereceptors and reduces rhinorrhea and lacrimation, eliminates spasticity. Ascorbic acid  up for an increased  in acute respiratory viral diseases and influenza.
Research pharmacokinetics of the drug was conducted.

Indications

  • symptomatic treatment of acute respiratory viral infections, including influenza, including those involving rhinorrhea, lacrimation, rhinopharyngitis, myalgia, headache.

Contraindications

  • increased sensitivity to one component of the drug;
  • portal hypertension;
  • state alcohol or drugs;
  • renal failure;
  • phenyl ketonuria;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • diabetes;
  • hemochromatosis, sideroblastic anemia, thalassemia;
  • pregnancy;
  • lactation;
  • Children up to age 15 years.

Carefully:

  • congenital hyperbilirubinemia (Gilbert’s syndrome, Dubin-Johnson and Rotor);
  • angle-closure glaucoma;
  • liver failure;
  • viral, alcoholic hepatitis;
  • elderly age;
  • hyperoxaluria, nephrolithiasis;
  • prostatic hyperplasia.

Dosing and Administration
Inside. The contents of 1 sachet dissolved in a glass of warm water and drink regardless of the meal. A single dose – 1 sachet contents. If necessary repeat dose administered every 4 hours, but not more than four times within 24 hours. If the kidney, liver, in old age interval between doses must be increased to 8 hours.

If within 3 days after receiving testosterone propionate the drug did not reduce the observed symptoms, you should consult a doctor,

Side effect

Allergic reactions: skin rash, pruritus, urticaria, angioedema.

From the digestive system: dry mouth, nausea, vomiting, constipation, epigastric pain, long-term use at high doses – hepatotoxic effects, erosive and ulcerative lesions of the gastrointestinal tract, bleeding in the gastrointestinal tract.

Cardio-vascular system: tachycardia, increased blood pressure.

On the part of the central nervous system: decrease in speed of psychomotor reactions, fatigue, drowsiness, dizziness, insomnia.

From the urinary system: urinary retention, glycosuria, long-term use at high doses – nephrotoxicity.

From hemopoiesis system: long-term use at high doses – thrombocytopenia, anemia, methemoglobinemia.

Overdose symptoms (due to paracetamol): pale skin, loss of appetite, nausea, vomiting; gepatonekroz (necrosis due to the severity of intoxication is directly dependent on the degree of overdose). Toxic effects in adults may, after receiving more than 10-15 g of paracetamol: increased prothrombin time activity (through 12-48 h after administration). The detailed clinical picture of liver damage appear after 1-6 days. Rarely liver failure develops lightning speed and can be complicated by renal insufficiency (tubular necrosis).

Treatment: within the first 6 hours after the overdose – gastric lavage, administration of donor of testosterone propionate, and the synthesis of glutathione precursors – methionine for 8-9 hours after the overdose and acetyl cysteine for 8 hours The need for additional therapeutic (continued introduction of methionine in /. intravenous acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after the reception.

Interaction with other drugs

Conditional paracetamol:
Reduces the uricosuric drugs (drugs). Concomitant use of acetaminophen in high doses increases the effect of anticoagulant drugs (reduction synthesis of procoagulant factors in the liver).

Inductors microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication, even with a small overdose.

Prolonged use of barbiturates, reduces the effectiveness of paracetamol.

Ethanol contributes to the development of acute pancreatitis.

propionate

When applied topically, the drug is practically not absorbed, so its concentration is very small (by modern analytical methods are not defined) in the blood plasma.

Indications for use:

Applied with acute respiratory propionate illness with symptoms of rhinitis (runny nose), acute allergic rhinitis, sinusitis, otitis media with (as part of combination therapy to reduce swelling of the mucous nasopharynx) to facilitate rhinoscopy.

Contraindications:

Hypersensitivity to xylometazoline, hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, hyperthyroidism, surgical intervention on meninges (in history), pregnancy, lactation, children under 2 years old.

Do not use in the treatment of propionate and tricyclic antidepressants.

With care – diabetes.

Dosage and administration:

Adults and children over 6 years of age are administered 1-2 drops of 0.1% xylometazoline solution in each nostril 2-3 times a day.

Children from 2 to 6 years of use of 0.05% solution of 1-2 drops in each nostril 1-2 times a day. Do not use the drug more than 3 times a day and no more than 3-5 days. Do not use the drug without interruption for more than 3-5 days.

Side effects:

Frequent and / or long-term use – irritation and / or dryness of the nasal mucosa, burning, stinging, sneezing, hypersecretion; rare – swelling of the nasal mucosa, vomiting, headache, palpitations, increased blood pressure, insomnia, blurred vision, depression (long-term use of high doses).

Overdose:

Symptoms: increased side effects. Treatment: symptomatic under the supervision of a physician.

Interaction with other drugs:

Perhaps strengthening systemic effect, while the use of propionate inhibitors and tricyclic antidepressants.

Special instructions:

Before first use, plastic bottle cap screwed as possible. In this tire. which is on its inner side hole pierces. The cap is unscrewed, removed, and slightly pressing the bottle body, the solution is instilled into the nose. After opening the vial the drug pass 28 days.

Do not use the drug for a long time, for example, in chronic rhinitis.

Effects on ability to drive a vehicle or equipment:

Xylometazoline, in doses exceeding recommended, may propionate affect the ability to drive a vehicle or equipment.

test propionate

Recommended  is generally well tolerated. As with other drugs containing sulfonamides and pyrimethamine can cause the test propionate following side effects or hypersensitivity reactions.

Co Skin and appendages: rash, pruritus, urticaria, photosensitivity reactions and slight hair loss. Usually, these effects are mild and disappear on their own after the withdrawal of the drug. In rare cases, particularly in patients with hypersensitivity can develop such serious (possibly life-threatening), skin reactions like erythema multiforme, Stevens-Johnson syndrome and Lyell’s syndrome, exfoliative dermatitis, toxic epidermal necrolysis.

In case of skin reactions, stop taking the drug and consult a doctor.

On the part of the hemopoietic system : rarely – leukopenia, thrombocytopenia and megaloblastic anemia, usually asymptomatic, aplastic anemia, hemolytic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia. Very rarely – agranulocytosis or purpura, as a rule, these changes are reversible after discontinuation of the drug.

From the gastrointestinal tract : the feeling of fullness, nausea; rarely – vomiting, diarrhea, stomatitis, glossitis, abdominal pain, hepatitis, pancreatitis, hepatocellular necrosis. Described isolated cases of transient increase of liver enzymes, as well , will coincide with the appointment of Fansidar.

From the nervous system , depression, convulsions, ataxia, hallucinations, tinnitus, insomnia, nervousness, peripheral neuritis.

On the part of the urinary tract : renal failure, interstitial nephritis, increased blood urea nitrogen and serum creatinine, toxic nephrosis with oliguria and anuria, crystalluria.

Other: sometimes – general weakness, apathy, fatigue, muscle weakness, headache, dizziness, chills, conjunctival injection, and sclera, drug fever and polyneuritis, anaphylactoid reactions, periorbital edema, arthralgia, periarteritis nodosa, lupus-like syndrome; rarely – pulmonary infiltrates, similar to those with eosinophilic or allergic alveolitis. If during treatment Fansidar symptoms such as cough or shortness of breath, you should stop the drug. Also disclosed are isolated cases of serum sickness and allergic pericarditis, myocarditis.

The sulfonamides are similar in chemical structure to some goitrogens, diuretics (acetazolamide and thiazides) and oral hypoglycemic agents. Due to the cross-reactivity between these drugs in patients receiving sulfonamides, rarely occur polyuria and hypoglycemia.

 

Overdose

 

With imptomy : loss of appetite, headache, nausea, vomiting, signs of excitement, sometimes convulsions and haematological changes (megaloblastic anemia, leukopenia, thrombocytopenia), glossitis, crystalluria.

Treatment: in acute poisoning – washing stomach or vomiting, fluid replacement; in convulsions – parenteral administration of diazepam or barbiturates. Monitoring of renal function, liver and repeated determination of blood cells within 4 weeks after the overdose. In test propionate identifying reducing blood platelets and leukocytes administered intramuscular calcium folinate (leucovorin) at a dose of 5-15 mg / day for 3 or more days.

 

Interaction with other drugs

 

You should not assign Fansidar simultaneously with trimethoprim or trimethoprim combination with sulfonamides, because it can enhance the violation of folic acid metabolism and the subsequent development of hematologic adverse reactions.

There are reports of a possible increase in the frequency and severity of adverse reactions strengthening while appointing Fansidar with chloroquine, compared with monotherapy Fansidar.

 

special instructions

 

It should strictly avoid excessively long exposure to the sun.

Patients should be informed that a sore throat, fever, cough, shortness of breath or purple may be the first signs of serious side effects. In particular, taking test propionate should stop immediately at the first signs of skin rash, significant reduction in the number of blood cells, bacterial or fungal superinfection.

If the drug is continued for more than 3 months, it is recommended to regularly monitor hematologic parameters, “liver” enzymes and crystalluria.

Chronic administration of high doses of the drug, for example, in the treatment of toxoplasmosis for the prevention of folic acid deficiency prescribe folic acid and calcium folinate.