Tag Archives: testosterone propionate

testosterone propionate

Paracetamol has analyeziruyuschim and antipyretic action. Pheniramine – blocker of testosterone propionatereceptors and reduces rhinorrhea and lacrimation, eliminates spasticity. Ascorbic acid  up for an increased  in acute respiratory viral diseases and influenza.
Research pharmacokinetics of the drug was conducted.

Indications

  • symptomatic treatment of acute respiratory viral infections, including influenza, including those involving rhinorrhea, lacrimation, rhinopharyngitis, myalgia, headache.

Contraindications

  • increased sensitivity to one component of the drug;
  • portal hypertension;
  • state alcohol or drugs;
  • renal failure;
  • phenyl ketonuria;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • diabetes;
  • hemochromatosis, sideroblastic anemia, thalassemia;
  • pregnancy;
  • lactation;
  • Children up to age 15 years.

Carefully:

  • congenital hyperbilirubinemia (Gilbert’s syndrome, Dubin-Johnson and Rotor);
  • angle-closure glaucoma;
  • liver failure;
  • viral, alcoholic hepatitis;
  • elderly age;
  • hyperoxaluria, nephrolithiasis;
  • prostatic hyperplasia.

Dosing and Administration
Inside. The contents of 1 sachet dissolved in a glass of warm water and drink regardless of the meal. A single dose – 1 sachet contents. If necessary repeat dose administered every 4 hours, but not more than four times within 24 hours. If the kidney, liver, in old age interval between doses must be increased to 8 hours.

If within 3 days after receiving testosterone propionate the drug did not reduce the observed symptoms, you should consult a doctor,

Side effect

Allergic reactions: skin rash, pruritus, urticaria, angioedema.

From the digestive system: dry mouth, nausea, vomiting, constipation, epigastric pain, long-term use at high doses – hepatotoxic effects, erosive and ulcerative lesions of the gastrointestinal tract, bleeding in the gastrointestinal tract.

Cardio-vascular system: tachycardia, increased blood pressure.

On the part of the central nervous system: decrease in speed of psychomotor reactions, fatigue, drowsiness, dizziness, insomnia.

From the urinary system: urinary retention, glycosuria, long-term use at high doses – nephrotoxicity.

From hemopoiesis system: long-term use at high doses – thrombocytopenia, anemia, methemoglobinemia.

Overdose symptoms (due to paracetamol): pale skin, loss of appetite, nausea, vomiting; gepatonekroz (necrosis due to the severity of intoxication is directly dependent on the degree of overdose). Toxic effects in adults may, after receiving more than 10-15 g of paracetamol: increased prothrombin time activity (through 12-48 h after administration). The detailed clinical picture of liver damage appear after 1-6 days. Rarely liver failure develops lightning speed and can be complicated by renal insufficiency (tubular necrosis).

Treatment: within the first 6 hours after the overdose – gastric lavage, administration of donor of testosterone propionate, and the synthesis of glutathione precursors – methionine for 8-9 hours after the overdose and acetyl cysteine for 8 hours The need for additional therapeutic (continued introduction of methionine in /. intravenous acetylcysteine) is determined by the concentration of paracetamol in the blood, as well as the time elapsed after the reception.

Interaction with other drugs

Conditional paracetamol:
Reduces the uricosuric drugs (drugs). Concomitant use of acetaminophen in high doses increases the effect of anticoagulant drugs (reduction synthesis of procoagulant factors in the liver).

Inductors microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes the possibility of severe intoxication, even with a small overdose.

Prolonged use of barbiturates, reduces the effectiveness of paracetamol.

Ethanol contributes to the development of acute pancreatitis.