test prop dosage

After a single oral pyrimethamine maximum plasma concentrations test prop dosage are reached after approximately 4 h. The distribution of sulfadoxine and pyrimethamine is respectively 0.14 and 2.3 l / kg. When receiving 1 tablet per week (recommended dosage for prevention of malaria in adults) can be expected that the average equilibrium plasma pyrimethamine concentration was 0.15 mg / L (about 4 weeks), and sulphadoxine. Protein binding is approximately 90% for both pyrimethamine and sulfadoxine for. Pyrimethamine and sulfadoxine cross the placental barrier and is excreted in breast milk.

Metabolism

About 5% is in blood sulfadoxine as acetylated metabolite, about 2-3% – as glucuronide. Pyrimethamine biotransformation to form several metabolites.

breeding

For both components characterized by a relatively . Its average value pyrimethamine is about 100 hours, and sulphadoxine – approximately 200 hours. As pyrimethamine and sulfadoxine derived mainly via the kidneys.

 

Patients with malaria pharmacokinetic parameters after a single dose may be different from those of healthy individuals, depending on the population.
Patients with renal insufficiency can be expected to slow excretion Fansidar components.

 

testimony

 

Malaria, especially caused by P. of falciparum , resistant to other antimalarials.
Fansidar is not recommended for routine prophylaxis of malaria.

Prevention of malaria test prop dosage is carried out only in areas endemic for P. of falciparum , which are sensitive to Fansidar, as well as in the case of contraindications or absence of other antimalarials . Parasitic infection: toxoplasmosis treatment and prevention of Pneumocystis carinii infection.

 

Contraindications

 

Hypersensitivity to sulfonamides or any other components of the preparation.
The documented megaloblastic anemia due to folic acid deficiency.
Children under the age of 2 months.

For prophylactic (prolonged) applications: severe renal or hepatic failure, blood dyscrasias, pregnancy and lactation.

 

Carefully

 

Pregnancy.

 

Pregnancy and lactation

The drug category C.

Limited experience of test prop dosage in the treatment or prophylaxis in pregnant women does not indicate harmful effects of drugs on the fetus, which could be fear based on the results of animal experiments.However, Fansidar can be administered during pregnancy only if the absolute indications, carefully weighing the expected benefit to the mother and the potential risk to the fetus.

Women of childbearing potential should use contraception during prophylactic and for 3 months after the last dose.

Nursing mothers should not take Fansidar, otherwise at the time of treatment requires transfer to artificial feeding.

 

Dosing and Administration

 

Tablets should be taken after a meal, without chewing and drinking plenty of water.

Treatment of uncomplicated malaria

The standard scheme of therapy of severe or cerebral malaria is receiving quinine for 7-10 days. Admission quinine can be shortened to 2-3 days if the therapy after a single dose of quinine .Sequential therapy with quinine and Fansidar effectively prevents relapses, often marked with quinine monotherapy.

 

malaria prevention

Malaria risk should be carefully weighed against the risk of serious adverse reactions to the drug.

If  is assigned to the prevention, the physician is obliged to obtain information about the intolerance of sulfonamides, to indicate to the patient at increased risk and the need for an immediate withdrawal of the drug with the appearance of skin reactions.

To prevent malaria, the first dose of  should be taken one week before arrival in an endemic area; then continue taking the drug in the above doses for the duration of stay and for the first 4-6 weeks after leaving the area.

The duration of prophylaxis is not more than 2 years experience as a long-term use of the drug is absent.

 

Emergency self-malaria therapy

Fansidar can be used as a means to provide independent emergency care in cases when medical help is not available. Self-treatment is a single admission test prop dosage under the scheme set out in the section“Treatment of uncomplicated malaria, a single dose of the drug.”

 

The patient should consult a doctor as soon as possible, even if he feels fully recovered, to confirm the diagnosis, as well as, if necessary, additional treatment.