test propionate

Recommended  is generally well tolerated. As with other drugs containing sulfonamides and pyrimethamine can cause the test propionate following side effects or hypersensitivity reactions.

Co Skin and appendages: rash, pruritus, urticaria, photosensitivity reactions and slight hair loss. Usually, these effects are mild and disappear on their own after the withdrawal of the drug. In rare cases, particularly in patients with hypersensitivity can develop such serious (possibly life-threatening), skin reactions like erythema multiforme, Stevens-Johnson syndrome and Lyell’s syndrome, exfoliative dermatitis, toxic epidermal necrolysis.

In case of skin reactions, stop taking the drug and consult a doctor.

On the part of the hemopoietic system : rarely – leukopenia, thrombocytopenia and megaloblastic anemia, usually asymptomatic, aplastic anemia, hemolytic anemia, hypoprothrombinemia, methemoglobinemia, eosinophilia. Very rarely – agranulocytosis or purpura, as a rule, these changes are reversible after discontinuation of the drug.

From the gastrointestinal tract : the feeling of fullness, nausea; rarely – vomiting, diarrhea, stomatitis, glossitis, abdominal pain, hepatitis, pancreatitis, hepatocellular necrosis. Described isolated cases of transient increase of liver enzymes, as well , will coincide with the appointment of Fansidar.

From the nervous system , depression, convulsions, ataxia, hallucinations, tinnitus, insomnia, nervousness, peripheral neuritis.

On the part of the urinary tract : renal failure, interstitial nephritis, increased blood urea nitrogen and serum creatinine, toxic nephrosis with oliguria and anuria, crystalluria.

Other: sometimes – general weakness, apathy, fatigue, muscle weakness, headache, dizziness, chills, conjunctival injection, and sclera, drug fever and polyneuritis, anaphylactoid reactions, periorbital edema, arthralgia, periarteritis nodosa, lupus-like syndrome; rarely – pulmonary infiltrates, similar to those with eosinophilic or allergic alveolitis. If during treatment Fansidar symptoms such as cough or shortness of breath, you should stop the drug. Also disclosed are isolated cases of serum sickness and allergic pericarditis, myocarditis.

The sulfonamides are similar in chemical structure to some goitrogens, diuretics (acetazolamide and thiazides) and oral hypoglycemic agents. Due to the cross-reactivity between these drugs in patients receiving sulfonamides, rarely occur polyuria and hypoglycemia.

 

Overdose

 

With imptomy : loss of appetite, headache, nausea, vomiting, signs of excitement, sometimes convulsions and haematological changes (megaloblastic anemia, leukopenia, thrombocytopenia), glossitis, crystalluria.

Treatment: in acute poisoning – washing stomach or vomiting, fluid replacement; in convulsions – parenteral administration of diazepam or barbiturates. Monitoring of renal function, liver and repeated determination of blood cells within 4 weeks after the overdose. In test propionate identifying reducing blood platelets and leukocytes administered intramuscular calcium folinate (leucovorin) at a dose of 5-15 mg / day for 3 or more days.

 

Interaction with other drugs

 

You should not assign Fansidar simultaneously with trimethoprim or trimethoprim combination with sulfonamides, because it can enhance the violation of folic acid metabolism and the subsequent development of hematologic adverse reactions.

There are reports of a possible increase in the frequency and severity of adverse reactions strengthening while appointing Fansidar with chloroquine, compared with monotherapy Fansidar.

 

special instructions

 

It should strictly avoid excessively long exposure to the sun.

Patients should be informed that a sore throat, fever, cough, shortness of breath or purple may be the first signs of serious side effects. In particular, taking test propionate should stop immediately at the first signs of skin rash, significant reduction in the number of blood cells, bacterial or fungal superinfection.

If the drug is continued for more than 3 months, it is recommended to regularly monitor hematologic parameters, “liver” enzymes and crystalluria.

Chronic administration of high doses of the drug, for example, in the treatment of toxoplasmosis for the prevention of folic acid deficiency prescribe folic acid and calcium folinate.